Therapy of acute vulvovaginal candidiasis, vaginal microbiocenosis
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St. Petersburg State Budgetary Healthcare Institution "Youth Center" (GC DC "Yuventa"), St. Petersburg, Russia
The incidence of CVV has nearly doubled over the past 10 years and currently accounts for 30–45% of all infectious diseases affecting the vulva and vagina. According to researchers, 70–75% of women experience at least one episode of CVV in their lifetime, and in 5–10% of cases, the disease becomes recurrent [1–4]. Alongside clinically manifest disease (acute, chronic, or recurrent CVV), there is also asymptomatic vaginal colonization by yeast-like fungi [4].
Summary
Objective: To evaluate the efficacy and safety of the drug Ecofucin® (intravaginal suppositories) based on the time to achieve clinical and microbiological remission in patients with acute candidal vaginitis/vulvovaginitis.
Materials and methods: The study included female patients aged 18 to 45 years with acute candidal vaginitis/vulvovaginitis. They were divided into two groups: the main group (36 patients) received Ecofucin® intravaginally (natamycin 100 mg with lactulose 300 mg); the control group (36 patients) received Pimafucin® suppositories (natamycin 100 mg) once daily for 6 days. The efficacy and safety of the study drugs were assessed based on examination results, laboratory tests, and patient diary entries. Follow-up visits were conducted on days 4, 7, and 37 (±2) from the start of treatment (or on day 30 (±2) after the end of therapy).
Results: The combination of the antifungal drug natamycin and a prebiotic in the intravaginal suppositories promotes faster achievement of clinical remission and complete elimination of the CVV pathogen, leading to intensive growth of lactobacilli, which are the main competitors of yeast-like fungi in the vaginal microbiocenosis. The study demonstrated good tolerability of Ecofucin by the patients, and no side effects were recorded during the study.
Keywords: candidal vulvovaginitis, vaginal microbiocenosis, lactobacilli.
For citation: Krotin P.N., Kirilenko O.V. Combination of an antifungal drug and a prebiotic in the therapy of acute candidal vulvovaginitis. RMJ. Mat' i ditya [Mother and Child]. 2019;2(*):1–7.
The full text of the article is available in the file: "Combination of an Antifungal Drug and a Prebiotic in the Therapy of Acute Candidal Vulvovaginitis"
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