Ekofucin® vaginal suppositories 100 mg
Ecofucin® is an antifungal drug for the treatment of thrush, containing a prebiotic. It provides targeted local action at the site of infection: it acts on the causative agent of thrush and stimulates the growth of the body's own lactobacilli, promoting the restoration of the vaginal microflora.
Description
Active Substance
Natamycin
Dosage Form and Composition
Vaginal suppositories 100 mg, 3 or 6 suppositories per pack.
Active substance: natamycin (calculated as 100% substance) – 100 mg;
Excipients: lactulose – 300 mg, macrogolglycerol hydroxystearate – 200 mg, colloidal silicon dioxide – 20 mg, hard fat up to 2300 mg.
Indications for Use
Vaginitis, vulvitis, vulvovaginitis caused by fungi of the genus Candida.
Contraindications
Hypersensitivity to the components of the drug.
Dosage and Administration
One suppository daily for 3–6 days.
The suppository is inserted deep into the vagina while lying down, once daily at bedtime.
The duration of the treatment course (3-6 days) is determined individually. It is recommended to continue treatment for a few more days after the symptoms disappear. The use of suppositories should be interrupted during menstruation. During treatment, it is not necessary to abstain from sexual intercourse, but it is recommended to examine sexual partners and, if candidal infection is detected, to conduct a course of treatment. Barrier methods of contraception should be used during treatment.
Use during Pregnancy and Breastfeeding
Ekofucin® can be used from the first trimester of pregnancy and during breastfeeding
Pharmacy Supply Terms
Over-the-counter
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Instructions for Use of Ekofucin® vaginal suppositories 100 mg
International Nonproprietary Name: natamycin
Trade Name of the Drug: Ekofucin®
Dosage Form: vaginal suppositories
Composition per one suppository:
Active substance: natamycin (calculated as 100% substance) – 100 mg;
Excipients: lactulose – 300 mg, macrogol glyceryl hydroxystearate – 200 mg, colloidal silicon dioxide – 20 mg, hard fat (Suppocire AM) up to 2300 mg.
Description
Torpedo-shaped suppositories from almost white to light brown in color. The presence of white specks is allowed. The presence of an air core or a funnel-shaped depression is allowed.
Pharmacotherapeutic Group
Antifungal agent
ATC Code: G01AA02
Pharmacological Properties
Pharmacodynamics
Natamycin is a polyene antifungal antibiotic from the macrolide group with a broad spectrum of action. It has a fungicidal effect. It binds to sterols in cell membranes, disrupting their integrity and functions, which leads to the death of microorganisms.
It is active against most pathogenic yeast-like fungi (especially Candida albicans), yeasts (Torulopsis and Rhodotorula), as well as other pathogenic fungi (Aspergillus, Penicillium.). It is less active against dermatophytes (Trichophyton, Microsporum, Epidermophyton). It does not affect gram-positive and gram-negative bacteria in vitro.
Resistance to natamycin is not encountered in clinical practice.
Pharmacokinetics
Ekofucin® does not have a systemic effect, as it is practically not absorbed through intact skin and mucous membranes.
Indications for Use
Vaginitis, vulvitis, vulvovaginitis caused by fungi of the genus Candida.
Contraindications
Hypersensitivity to the components of the drug.
Use during Pregnancy and Breastfeeding
The use of Ekofucin® is possible during pregnancy and lactation.
Dosage and Administration
For candidal vaginitis, vulvitis, vulvovaginitis: intravaginally, one suppository daily for 3–6 days.
After freeing from the contour packaging, the suppository should be inserted deep into the vagina while lying down, once daily at bedtime.
The duration of the course of treatment is determined individually. It is recommended to continue treatment for a few more days after the symptoms of the disease disappear. The use of suppositories should be interrupted during menstruation.
In cases of persistent vaginitis caused by Candida albicans, natamycin tablets for oral administration are additionally prescribed: 1 tablet 4 times a day for 10-20 days to eliminate the focus of candidal infection in the intestine.
Side Effects
Local application may cause slight irritation and a burning sensation at the site of application.
Overdose
There have been no reports of overdose with Ekofucin® to date.
Drug Interactions
No drug interactions of Ekofucin® with other medicinal products have been described.
Special Instructions
During vaginal application, the suppositories melt under body temperature, turning into a foamy mass, which promotes even distribution of natamycin over the vaginal mucosa.
During treatment, it is not necessary to abstain from sexual intercourse, but it is recommended to examine sexual partners and, if candidal infection is detected, to conduct a course of treatment with natamycin. Barrier methods of contraception should be used during treatment.
Effect on Ability to Drive and Operate Machinery
The use of Ekofucin® does not affect the ability to drive vehicles and operate machinery.
Packaging
Vaginal suppositories 100 mg.
3 or 6 suppositories in a PVC/PE blister strip.
1 or 2 blister packs of 3 suppositories each, or 1 blister pack of 6 suppositories, together with the instructions for use in a cardboard carton.
Storage Conditions
Store in a dry place, protected from light, at a temperature not exceeding 25 °C.
Keep out of reach of children.
Legal Status
Over-the-counter.
Shelf Life
2 years. Do not use after the expiration date printed on the package.
Name and Address of the Marketing Authorization Holder / Organization for Claims:
JSC "AVVA RUS", Russia, 121614,
Moscow, ul. Krylatskie Kholmy, 30, building 9.
tel: (495) 956-75-54.
avva.com.ru
ecoantibiotic.ru
Manufacturer:
JSC "AVVA RUS", Russia,
610044, Kirov region, Kirov, ul. Luganskaya, 53a.
tel: +7 (8332) 25-12-29.
avva.com.ru
ecoantibiotic.ru
