Contract Development

Contract Development

A wide range of services

Chromatography and analytical groups perform quality control of medical products, pharmaceutical substances, excipients (among them HPLC and GC methods); develop method analysis of new medical products; validate analytical methods.

Employees of the standardization group prepare registration dossier (including CTD format), develop in-house standards and procedures, and support quality system.

Technology-and-testing laboratory develops composition and technology of new medical products products, validate technological processes, carries out activity on scaling-up.

R&D Laboratory in cooperation with R&D Department perform the following science-research and design-and-experimental activities:

  • Development of composition and technology of new medical products and their further launching into manufacture
  • Transfer of medical products technology to commercial scale
  • Medical products, pharmaceuticals and excipients testing
  • Stability testing of medical products and pharmaceutical substances
  • Development and validation of method analysis of medical products
  • Preparation of registration documents for medical products and pharmaceutical substances
  • Research activities focused on new pharmaceutical products development
  • Support of registration of medicines and pharmaceutical substances and clinical trial authorization.
Contract Development

R&D Laboratory has experience in pharmaceutical development of the below mentioned pharmaceutical forms:

  • Tablets
  • Coated tablets
  • Dispersible tablets
  • Modified release tablets
  • Capsules
  • Suppositories
  • Syrups
  • Emulsions
  • Powders/granules for suspension/oral liquids
  • Oral gels

Execution Timeframes

Development of quality control methods of medical products quality control
Methods of development of medicines quality control
Manufacturing and quality control of pilot batches s of medicines
Organization of industrial production and technical documents preparation
Timeframes of stability investigation are set in accordance with ICH Q1 recommendations.

Quality Assurance

R&D Laboratory provides high quality implementation of the services due to availability of:
Rated experimental and industrial facilities
Full package of up-to-date technological and analytical equipment
Efficient staff with rich experience in development and quality control of medical products


In order to accomplish the above mentioned tasks R&D Laboratory applies technological and analytical equipment produced by the leading global manufacturers.

Chromatography and analytical group develops and validate analytical methods for excipients, pharmaceutical forms under development and active pharmaceutical ingredients in compliance with CPMP/ICH/381/95, European Pharmacopoeia and USP.

In order to conduct necessary testing properly. Chromatography group is equipped with up-to-date analytical devices (HPLC, gas-liquid chromatography, dissolution test machines etc.) produced by:

Shimadzu (Japan)
Agilent Technologies
Millipore (USA)
Pharma Test (Germany)
HPLC devices are equipped with modern multi-channel gradient pumps, autosamplers, analytical thermostat columns and various types of detectors. Flexible modular systems render possibility to develop, validate and reconstruct methods of diverse complexity levels.
Scaling and technology transfer is possible due to the JSC AVVA RUS’s production capacity and also can be moved to the working space of customer with further consultative support by R&D’s personnel.
Standardization group carries out investigation of medical products and pharmaceutical substances stability in different climate conditions (stress-testing, accelerated tests of stability, long-term research, photo-stress study) in accordance with ICH Q1.

Main thermal modes are listed below:
t, C Relative degree of humidity, % Expiry date Place of storage
25±2 60±2 Before expiry date (long-term testing) Arbitrage storage stockroom
30±2 65±2 12 months (midterm testing) Climate chamber YP-720SDP
40±2 75±2 6 months (accelerated testing) Climate chamber KBF-240
Stability testing in the temperature ranges 0 ºС-70 ºС and humidity ranges 10%-80%, stress-testing, photo-stress study. Climate chamber KBF P 240

Climate chamber KBF-240

Climate chamber KBF-240
Climate chamber KBF-240 is used for storage of medical products at set temperature and humidity.

Climate chamber YP-720SDP

Climate chamber YP-720SDP
Climate chamber YP-720SDP is used for storage of medical products at set temperature and humidity.


Total number of laboratory employees constitutes 30 people, 27 of them have specialized university degrees. Personnel are experienced in the fields of manufacturing, medical products quality control and analytical chemistry. R&D’s personnel take annual professional course at the leading education centers of Moscow, Saints-Petersburg, Yekaterinburg and other cities and upgrade their professional skills due to regular in-house training in compliance with GMP.

Our partners

We provide contract services on pharmaceutical development for the companies like CJSC R-Farm, Nearmedic Plus Ltd., N.C. Pharmaceuticals Ltd., Functional Products Ltd., Teva Ltd. etc.

Contract Development

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